منابع مشابه
Septic cardiomyopathy
Depression of left ventricular (LV) intrinsic contractility is constant in patients with septic shock. Because most parameters of cardiac function are strongly dependent on afterload, especially in this context, the cardiac performance evaluated at the bedside reflects intrinsic contractility, but also the degree of vasoplegia. Recent advances in echocardiography have allowed better characteriz...
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Sepsis is the manifestation of the immune and inflammatory response to infection that may ultimately result in multi organ failure. Despite the therapeutic strategies that have been used up to now, sepsis and septic shock remain a leading cause of death in critically ill patients. Myocardial dysfunction is a well-described complication of severe sepsis, also referred to as septic cardiomyopathy...
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Septic cardiomyopathy is a separate clinical entity clearly distinct from myocarditis on histological grounds. Physiologically it characteristically presents, unlike other types of heart failure, with normal or increased cardiac output with normal or low preload pressures & a reduced systemic vascular resistance. Speckle tracking echocardiography is now the diagnostic tool of choice for detecti...
متن کاملInvolvement of Mitochondrial Disorders in Septic Cardiomyopathy
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains a leading cause of death worldwide, despite the development of various therapeutic strategies. Cardiac dysfunction, also referred to as septic cardiomyopathy, is a frequent and well-described complication of sepsis and associated with worse clinical outcomes. Recent research...
متن کاملHighlight: Mitochondrial Mechanisms in Septic Cardiomyopathy
The review article, “Mitochondrial Mechanisms in Septic Cardiomyopathy” by Cimolai and colleagues, examines the role that mitochondria may play in the pathogenesis of cardiac dysfunction, a well-described, life-threatening complication in patients with severe sepsis and septic shock. Despite current therapies that mostly aim to reduce systemic infection and inflammation, sepsis remains the bigg...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2017
ISSN: 0090-3493
DOI: 10.1097/ccm.0000000000002239